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Understanding the Interaction Between Enzymes and Nanomaterials
(North Dakota State University, 2019)
The rapid development of nanoparticles (NPs) has impacted many fields including energy efficiency, material science, biosensing, and medical therapeutics. Recently, NPs have been utilized to immobilize enzymes. The so-formed ...
Mechanistic Studies on the Methionine Aminopeptidase and Peptide Deformylase Catalyzed Reactions
(North Dakota State University, 2013)
In the search for novel antibiotic and therapeutic targets, methionine aminopeptidase (MetAP) and peptide deformylase (PDF) have recently been identified as eminently compelling. These enzymes are involved in the ...
Micro-/Nano- Materials Based Ultrasensitive Lateral Flow Nucleic Acid Biosensors
(North Dakota State University, 2017)
Ultrasensitive detection of nucleic acids plays a very important role in the field of molecular diagnosis for the detection of various diseases. Lateral flow biosensors (LFB) are convenient, easy-to-use, patient friendly ...
Exciton Diffusion, Transport, and Localization in Conjugated Polymers
(North Dakota State University, 2013)
Conjugated polymers are wide bandgap semiconductors which have a series of conjugated π-orbitals that extend along the polymer ‘backbone’. The π-orbital conjugation can be disrupted by twisting of the polymer, affecting ...
Identification of Novel RPA-Protein Interactions Using the Yeast Two Hybrid Assay and Identification of Regions Important for Interaction Between RPA and Rad24
(North Dakota State University, 2013)
Replication Protein A (RPA) [Replication Factor A (RFA) in yeast] is an ssDNA binding protein
composed of Rpa1, Rpa2, and Rpa3 and involved in numerous DNA processing pathways such as
Replication, Recombination, and Repair. ...
Infrared Diode Laser Spectroscopic Study of Combustion Related Kinetics
(North Dakota State University, 2016)
In the introduction section background into the subject of combustion chemistry is presented. The topics included are combustion mechanisms, combustion pollutants, and infrared absorption spectroscopy. Chapter two describes ...
Acyl Imidazole : A Promising Template for Asymmetric Lewis and Brønsted Acid Mediated 1,3-Dipolar Cycloadditions
(North Dakota State University, 2011)
Construction of chiral complex molecules continues to be a challenge for organic chemists all over the world and to address this challenge numerous methodologies have been developed. 1,3-Dipolar cycloaddition reactions is ...
Biochemical and Epidemiological Analysis of Mycobacterium Avium Subspecies Paratuberculosis and Investigation of its Relationship to Crohn's Disease in Humans
(North Dakota State University, 2011)
Background: Crohn's disease is a chronic inflammatory disease of the intestine in humans, with no known cause. Johne's disease is a chronic intestinal disease of ruminants caused by Mycobacterium avium suhspecies ...
Understanding Binding-Induced Disorder-to-Order And Conformational Transitions in Proteins that Regulate Autophagy
(North Dakota State University, 2018)
Autophagy, a cellular homeostasis process that degrades and recycles cytosolic contents, is regulated at various stages by protein interactions. BECN1 regulates autophagy through interactions with diverse proteins via ...
Delineating Signaling Mechanisms Involved in Lymphocyte Chemotaxis, Immune Homeostasis and Allergic Asthma
(North Dakota State University, 2015)
The vasoactive intestinal peptide (VIP) signaling axis constitutes VIP and its two G protein coupled receptors (GPCR) termed vasoactive intestinal/pituitary adenylate cyclase activating polypeptide (VPAC) 1 and 2. This ...