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Enzyme Behavior in Synthetic Materials and Structural Implications for Rational Design
(North Dakota State University, 2020)
Combining enzymes with synthetic materials is the new frontier of biocatalysis, materials science, and protein engineering. Enzymes are biological macromolecule catalysts with incredible efficiency and specificity that are ...
Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling Reaction of Aromatic Esters and Aromatic Diesters with Arylboronic Acids
(North Dakota State University, 2020)
The palladium-catalyzed cross-coupling reactions for the functionalization of the ester bond provides a significant overall improvement in the catalytic system as compared to aryl halides/pseudo-halides electrophilic ...
Investigating the Role of BECN1 Conformationally Flexible Regions and Invariant Cys-x-x-Cys Motifs in Autophagy
(North Dakota State University, 2020)
Autophagy is an essential catabolic cellular homeostasis process conserved in all eukaryotes. BECN1, a key autophagy protein involved in autophagosome nucleation, comprises of a large, poorly conserved, N-terminal intrinsically ...
Designing Ru Catalysts for Selective C-H Bond Oxidation Reactions
(North Dakota State University, 2020)
Typically, C-H bond oxidation proceeds via formation of high-valent metal oxo species. Attaining a high oxidation state of the metal complex is critical as it is the key step for many catalytic processes. Understanding ...
VIP Induces Snail1, A Master EMT Regulator: Upregulation in A375 Cancer Cells
(North Dakota State University, 2021)
VIP is neurotransmitter with pleiotropic functions in mammals. It is expressed by a large number of tissues, including the CNS, PNS, innate and adaptive immune systems. VIP has two endogenous G-protein coupled receptors, ...
Influence of Organic and Inorganic Passivation on the Photophysics of Cadmium Chalcogenide and Lead Chalcogenide Quantum Dots
(North Dakota State University, 2020)
Quantum dots (QDs) are promising materials for photovoltaic (PV) and light-emitting diode (LED) applications due to their unique properties: photostability, size-tunable absorptivity, and narrow line-width emission. These ...
Surface and Interface Effects on the Photoexcited Process of Silver Nanoclusters, and Lead & Cadmium Chalcogenide Nanocrystals
(North Dakota State University, 2020)
The surface and interface of the metal nanoclusters and semiconducting nanomaterials play a key role in determining the electronic structure and overall photophysical properties. A single strand DNA stabilizes the metal ...
Seeing the Forest for the Trees: An Exploration of Student Problem Solving and Reasoning with 1H NMR Spectral Features
(North Dakota State University, 2020)
Nuclear magnetic resonance (NMR) spectroscopy is vital to synthesis and provides rich problem-solving opportunities for organic chemistry students. However, little is known about 1H NMR spectroscopy instruction or how ...
Scrutinizing the Role of Ambipolar Units in the Donor-Acceptor Framework
(North Dakota State University, 2021)
Conjugated polymers (CPs) are a class of materials that contradict what is commonly considered when people hear the terms plastics and electronics. While these two phrases are generally considered exclusive, CPs combine ...
A Metal Catalyzed Approach for Heterocycle Coupling Reactions
(North Dakota State University, 2021)
Heterocycles are cyclic compounds which contain atoms from at least two different elements. The work in this thesis describes methods we developed for the direct chemical transformation of indole heterocycles with various ...