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Biophysical Studies of Ligand Binding to Human Histone Deacetylase-8
(North Dakota State University, 2014)
Due to an involvement in various patho-physiological conditions, human histone deacetylases (HDACs) are high priority drug targets for the treatment of several diseases, such as cancer, heart failure, neurodegeneration, ...
Characterizing the Roles of Exit Tunnel Residues in Ligand Binding and Catalysis of Histone Deacetylase-8
(North Dakota State University, 2014)
Histone deacetylases are an important class of enzymes that catalyze the hydrolysis of acetyl-L-lysine side chains in histone and non-histone proteins to yield L-lysine and acetate, effecting the epigenetic regulation of ...
Identification of Active Sites in Heterogeneous Catalysis and Surface Chemistry Study of Alkanes Adsorption
(North Dakota State University, 2014)
Heterogeneous catalysis is considered the basis of the chemical industry. Surface science investigations on model catalysts have made significant contributions in gaining molecular level understanding of heterogeneously ...
New Strategies for Ruthenium Catalyzed C-C Bond Formation
(North Dakota State University, 2014)
Transition metal-catalyzed C-H bond activation allows direct functionalization of the ubiquitous C-H bonds in organic molecules to increase the molecular complexity. Since Murai's pioneering work in ruthenium catalyzed ...
Stereospecific Phototransformations of Atropisomeric Chromophores
(North Dakota State University, 2014)
Photochemical transformations are unique strategy in synthesis that enables us to
access complex and structurally diverse organic scaffolds. However, the challenges in controlling
the excited-state to perform stereoselective ...
Applications of Dithieno [3,2-B2',3'-D] Pyrroles and its Analogues to Conjugated Materials
(North Dakota State University, 2014)
The promise of semiconducting materials with tunable electronic and optical properties
that share the same mechanical flexibility, low production costs and ease of processing displayed
by traditional polymers fuels the ...
Stereospecitic Phototransformations of Axially Chiral Chromaphores
(North Dakota State University, 2014)
Video summarizing Ph.D. dissertation for a non-specialist audience.
Synthesis and Characterization of 2,3-Difunctionalized Thieno[3,4-b]Pyrazine-Based Terthienyls Structure-Function Relationships and Side Chain Tunability
(North Dakota State University, 2014)
The ability to tune the physical, electronic, and optical properties of polymer precursors has garnered a great deal of interest in the conjugated organic materials field. The Rasmussen group has previously demonstrated ...
Enhanced Sensitivity of Lateral Flow Strip Biosensors Based on Enyzmatic Reaction and Nanomaterials
(North Dakota State University, 2014)
Ultrasensitive detection for trace amount of proteins plays pivotal role in the diagnosis of specific diseases in clinical application, basic discovery research and the improvement of proteomics. Recently, lateral flow ...