Browsing Chemistry & Biochemistry Doctoral Work by Issue Date
Now showing items 21-40 of 67
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Enhanced Sensitivity of Lateral Flow Strip Biosensors Based on Enyzmatic Reaction and Nanomaterials
(North Dakota State University, 2014)Ultrasensitive detection for trace amount of proteins plays pivotal role in the diagnosis of specific diseases in clinical application, basic discovery research and the improvement of proteomics. Recently, lateral flow ... -
Visual Detection of Cancer Biomarkers with Aptamer-Functionalized Gold Nanoparticles
(North Dakota State University, 2015)Cancer biomarkers may hold the key for the early detection of cancer, distinguishing between benign and malignant cells, and differentiating tumor types. The detection of cancer biomarkers can be used for cancer diagnosis, ... -
Novel Asymmetric Approaches for Construction of Small Molecules by Cyclization and Cycloaddition
(North Dakota State University, 2015)Development of novel asymmetric and catalytic methods for synthesizing small organic molecules containing hindered quaternary and tertiary centers is a major challenge and a dynamic area of investigation in synthetic organic ... -
Delineating Signaling Mechanisms Involved in Lymphocyte Chemotaxis, Immune Homeostasis and Allergic Asthma
(North Dakota State University, 2015)The vasoactive intestinal peptide (VIP) signaling axis constitutes VIP and its two G protein coupled receptors (GPCR) termed vasoactive intestinal/pituitary adenylate cyclase activating polypeptide (VPAC) 1 and 2. This ... -
Characterization of RPA2 N-terminal Function in the DNA Damage Response in Saccharomyces Cerevisiae
(North Dakota State University, 2015)In response to DNA damage, two general but fundamental processes occur in the cell: (1) a DNA lesion is recognized and repaired, and (2) concomitantly, the cell halts the cell cycle to provide a window of opportunity for ... -
Lateral Flow Nucleic Acid Biosensor for the Detection of Sexually Transmitted Diseases
(North Dakota State University, 2015)Nucleic acid detection is of central importance for the diagnosis and treatment of genetic diseases, infectious agents, bio-warfare agents, and drug discovery. Nucleic acid testing for diseases is exclusively performed in ... -
Atropisomeric Chromophores as Catalysts and Substrates for Asymmetric Light Induced Transformations
(North Dakota State University, 2016)Photochemical transformations hold a unique place as they can provide access to molecules with unique stereochemical and structurally complex scaffolds, thus serving as a complementary approach to thermal transformations. ... -
4-Dimethylamino Pyridine (DMAP) Catalyst with Fluxional Chirality: Synthesis and Applications
(North Dakota State University, 2016)Organocatalysis using small organic molecules to catalyze organic transformations, has emerged as a powerful synthetic tool that is complementary to metal-catalyzed transformations and remarkably promote stereoselective ... -
Photons in Action: Asymmetric Synthesis and Polymer Degradation
(North Dakota State University, 2016)Light is an environmentally benign and renewable source of energy that finds wide application in the field of science. This dissertation explores two areas of chemistry that utilizes light extensively viz., asymmetric ... -
Structural Studies of the Mechanism by Which BCL-2 and Beclin Proteins Regulate Autophagy and Apoptosis
(North Dakota State University, 2016)Autophagy and apoptosis are catabolic pathways essential for homeostasis in all eukaryotes. While autophagy usually promotes cell-survival by enabling degradation and recycling of damaged macromolecules, apoptosis is the ... -
Effect of Surface Ligands and Surface Defects on the Electronic and Optical Properties of Quantum Dots
(North Dakota State University, 2016)Quantum dots (QDs) have drawn a special attention since recent past due to their properties such as broad range absorption ability, size tunable narrow emission, high extinction coefficients, and charge carriers ability. ... -
Late Transition Metal-Catalyst Development for Alkyne Coupling Reactions
(North Dakota State University, 2016)Alkynes are versatile and valuable synthetic precursors in a variety of organic transformations and have found tremendous applications in materials science and pharmaceutical chemistry. In recent years, there has been a ... -
Visible Light Photocatalysis of N-N Bond Based Compounds
(North Dakota State University, 2016)The well-established principles of organic photochemistry, offer chemists the fundamental understanding and tools for studying light induced chemical transformations. Employing visible light for photocatalysis, one can ... -
Photons in Action: Asymmetric Synthesis and Polymer Degradation
(North Dakota State University, 2016)Video summarizing Ph.D. dissertation for a non-specialist audience. -
Ligand Binding and Catalysis in Selected Sirtuin Isozymes
(North Dakota State University, 2016)Due to their intimate roles in survival, longevity as well as pathogenesis via “epigenetic” and “metabolic” regulatory mechanisms, sirtuins have gained considerable interest toward undertaking detailed biochemical/biophysical ... -
Structural Basis for the Regulation of a Conserved TonB-dependent Iron Transport System via Cell-surface Signaling in Gram-negative Bacteria
(North Dakota State University, 2017)Cell-surface signaling (CSS) pathways are highly conserved systems in Gram-negative bacteria that allow the cell to efficiently respond to environmental stimuli through transcriptional regulation. Three distinct proteins ... -
Strategic Functionalization of Single Walled Carbon Nanotubes to Manipulate their Electronic and Optical Properties
(North Dakota State University, 2017)Single-walled carbon nanotubes (SWCNTs) are unique materials that exhibit chirality-specific properties due to their one-dimensional confinement. As a result, they are explored for a wide range of applications including ... -
Ultrasensitive Lateral Flow Nucleic Acid Biosensors Based on Novel Macro-/Nano-Materials
(North Dakota State University, 2017)Video summarizing a Ph.D. dissertation for a non-specialist audience. -
Micro-/Nano- Materials Based Ultrasensitive Lateral Flow Nucleic Acid Biosensors
(North Dakota State University, 2017)Ultrasensitive detection of nucleic acids plays a very important role in the field of molecular diagnosis for the detection of various diseases. Lateral flow biosensors (LFB) are convenient, easy-to-use, patient friendly ... -
Thiazole vs. Thiophene: Heterocycle Effects on the Properties of Fused-Ring Conjugated Materials
(North Dakota State University, 2017)Conjugated polymers and related molecular materials comprise a field of materials chemistry focused on the development of semiconducting organic plastics that find use in applications such as organic solar cells and organic ...