Chemistry & Biochemistry Doctoral Work: Recent submissions
Now showing items 1-20 of 70
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Structural Basis of Key Conserved Cell-Surface Signaling Pathways Involved in Iron Import
(North Dakota State University, 2024)Cell surface signaling (CSS) allows Gram-negative bacteria to transcriptionally regulate gene expression in response to external stimuli. CSS pathways involve three key components: an outer membrane transducer for sensing ... -
Investigating the role of BECN2 CCD interactions in canonical and non-canonical autophagy
(North Dakota State University, 2024)Autophagy is a conserved cell-survival pathway wherein old, damaged or harmful cellular components are surrounded by a double membrane vesicle called the autophagosome for lysosomal degradation and recycling. All eukaryotes ... -
Synthesis and Characterization of Thieno[3,4-b]pyrazine-Based Near-Infrared Material
(North Dakota State University, 2024)Since their first report in the 1800s, conjugated polymers have gained significant attention for their ability to exhibit the optical and electronic properties of inorganic semiconductors and the physical traits of organic ... -
Influence of Active Site Ligands and Nanoparticle Surfaces on Human Carbonic Anhydrase Isozymes
(North Dakota State University, 2010)Carbonic anhydrase (CA) is an ubiquitously distributed zinc containing metallo enzyme that catalyzes the reversible hydration of carbon dioxide to form bicarbonate and a proton. Existence of 16 isoenzymes of CA in the ... -
Differential Modulation of the Structural and Functional Characteristics of Human Matrix Metalloproteinase Isozymes upon Binding to Different Ligands
(North Dakota State University, 2010)Matrix metalloproteinases (MMPs) are a family of Zn2 + -dependent, Ca2 + -containing endoproteinases involved in tissue remodeling and degradation of the extracellular matrix (ECM). Human MMP isozymes are known to be ... -
Mechanistic Investigation of Catalytic Chlorite Decomposition by Chlorite Dismutase
(North Dakota State University, 2021)Water purification processes often involve chlorine-based disinfectants which consequently leads to formation of chloro oxyanions (ClOx−), potent water-soluble oxidizing agents. These chlorine species are kinetically stable ... -
Synthesis of Novel Biomass-derived Diol and Epoxide Monomers for Coatings Applications
(North Dakota State University, 2022)There are few monomers or precursors in the polymer industry that are more ubiquitous than bisphenol A (BPA). According to the CDC, about 5-6 billion pounds of BPA are produced worldwide annually. For the synthesis of ... -
Examining Thieno[3,4-b]pyrazine Through a Multifaceted Lens: From Extended Ring Functionalization to Ambipolar-Acceptor Copolymers
(North Dakota State University, 2022)A class of materials known as conjugated polymers (CPs) has been shown to integrate the physical properties of organic plastics such as low-weight, flexibility, and synthetic modularity with electronic semiconducting ... -
New Insights into Apoptosis-Inducing Factor Mediated Pro-Survival Activity
(North Dakota State University, 2022)Cancer is a group of diseases characterized by the uncontrolled growth of cells and is caused by the accumulation of genetic mutations that contribute to cell division, cell growth, and the DNA repair system. According to ... -
Scrutinizing the Role of Ambipolar Units in the Donor-Acceptor Framework
(North Dakota State University, 2021)Conjugated polymers (CPs) are a class of materials that contradict what is commonly considered when people hear the terms plastics and electronics. While these two phrases are generally considered exclusive, CPs combine ... -
Surface and Interface Effects on the Photoexcited Process of Silver Nanoclusters, and Lead & Cadmium Chalcogenide Nanocrystals
(North Dakota State University, 2020)The surface and interface of the metal nanoclusters and semiconducting nanomaterials play a key role in determining the electronic structure and overall photophysical properties. A single strand DNA stabilizes the metal ... -
Designing Ru Catalysts for Selective C-H Bond Oxidation Reactions
(North Dakota State University, 2020)Typically, C-H bond oxidation proceeds via formation of high-valent metal oxo species. Attaining a high oxidation state of the metal complex is critical as it is the key step for many catalytic processes. Understanding ... -
Investigating the Role of BECN1 Conformationally Flexible Regions and Invariant Cys-x-x-Cys Motifs in Autophagy
(North Dakota State University, 2020)Autophagy is an essential catabolic cellular homeostasis process conserved in all eukaryotes. BECN1, a key autophagy protein involved in autophagosome nucleation, comprises of a large, poorly conserved, N-terminal intrinsically ... -
Enzyme Behavior in Synthetic Materials and Structural Implications for Rational Design
(North Dakota State University, 2020)Combining enzymes with synthetic materials is the new frontier of biocatalysis, materials science, and protein engineering. Enzymes are biological macromolecule catalysts with incredible efficiency and specificity that are ... -
Seeing the Forest for the Trees: An Exploration of Student Problem Solving and Reasoning with 1H NMR Spectral Features
(North Dakota State University, 2020)Nuclear magnetic resonance (NMR) spectroscopy is vital to synthesis and provides rich problem-solving opportunities for organic chemistry students. However, little is known about 1H NMR spectroscopy instruction or how ... -
Influence of Organic and Inorganic Passivation on the Photophysics of Cadmium Chalcogenide and Lead Chalcogenide Quantum Dots
(North Dakota State University, 2020)Quantum dots (QDs) are promising materials for photovoltaic (PV) and light-emitting diode (LED) applications due to their unique properties: photostability, size-tunable absorptivity, and narrow line-width emission. These ... -
New Strategies for Transition Metal Catalyzed C-C and C-N Bond Formation
(North Dakota State University, 2018)Transition metal catalysis emerged as an essential tool in the field of organic chemistry. In this context, transition metal catalyzed C-H bond functionalization is considered as an alluring strategy as it occurs with the ... -
Synthesis and Design of Thiophene Materials: Effects of Ring Fusion and Metal Coordination
(North Dakota State University, 2019)Conjugated organic materials comprise a field of materials chemistry focused on the development of semiconducting organic plastics, popular applications of which are plastic solar cells and display technologies. One of the ... -
Structural Basis for the Regulation of a Conserved TonB-dependent Iron Transport System via Cell-surface Signaling in Gram-negative Bacteria
(North Dakota State University, 2017)Cell-surface signaling (CSS) pathways are highly conserved systems in Gram-negative bacteria that allow the cell to efficiently respond to environmental stimuli through transcriptional regulation. Three distinct proteins ... -
Understanding the Interaction Between Enzymes and Nanomaterials
(North Dakota State University, 2019)The rapid development of nanoparticles (NPs) has impacted many fields including energy efficiency, material science, biosensing, and medical therapeutics. Recently, NPs have been utilized to immobilize enzymes. The so-formed ...