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Novel Synthetic Routes to Complex Amines: the Catalytic Hydroamination of Alkynes and Hydroimination of Allenes
(North Dakota State University, 2016)
Amines are valuable targets for synthesis in contexts of both research and industrial applications. This work proposes two atom-economical methods—hydroamination (HAM) and hydroimination (HIM)—as C-N bond formation strategies. ...
Carbon Nanotubes-Based Lateral Flow Biosensor for Sensitive and Rapid Detection of DNA Sequence
(North Dakota State University, 2017)
Sensitive detection for DNA has drawn great attention in plenty of different areas such as genetics therapy and basic discovery research. Recently, nucleic acid lateral flow biosensor (NALFB) has gained considerable attention ...
Supramolecular Functionalization of Single-Walled Carbon Nanotubes
(North Dakota State University, 2013)
Single-walled carbon nanotubes (SWNTs) possess extraordinary mechanical strength, thermal and electrical conductivity. These properties make them very attractive in many applications in the fields of nanotechnology, ...
Characterizing the Roles of Exit Tunnel Residues in Ligand Binding and Catalysis of Histone Deacetylase-8
(North Dakota State University, 2014)
Histone deacetylases are an important class of enzymes that catalyze the hydrolysis of acetyl-L-lysine side chains in histone and non-histone proteins to yield L-lysine and acetate, effecting the epigenetic regulation of ...
Synthesis and Applications of Dialdehydes
(North Dakota State University, 2018)
Due to their reactivity and ease of functional group interconversions, aldehydes have wide-ranging applications in polymer synthesis, such as polyacetals, epoxy resins, and polyurethanes. Recently, room temperature synthesis ...
Identification of Aptamer Specific for Carcinoembryonic Antigen and its Analytical Applications
(North Dakota State University, 2017)
Carcinoembryonic Antigen (CEA) is an approved cancer biomarker by the Food and Drug Administration (FDA) for the early detection, diagnosis, and for the use in the regular screening of patients at high risk for the development ...
Identification of Novel RPA-Protein Interactions Using the Yeast Two Hybrid Assay and Identification of Regions Important for Interaction Between RPA and Rad24
(North Dakota State University, 2013)
Replication Protein A (RPA) [Replication Factor A (RFA) in yeast] is an ssDNA binding protein
composed of Rpa1, Rpa2, and Rpa3 and involved in numerous DNA processing pathways such as
Replication, Recombination, and Repair. ...
Infrared Diode Laser Spectroscopic Study of Combustion Related Kinetics
(North Dakota State University, 2016)
In the introduction section background into the subject of combustion chemistry is presented. The topics included are combustion mechanisms, combustion pollutants, and infrared absorption spectroscopy. Chapter two describes ...
Synthesis of Precursors to Non-isocyanate Polyurethanes
(North Dakota State University, 2018)
Biobased diamines are excellent precursors for the synthesis of non-isocyanate polyurethanes (NIPUs). We have prepared several biobased diamines using three different reactions for their synthesis. In the first method, we ...
The Development and Use of Chiral 4-Dimethylaminopyridine-N-Oxide as an Organocatalyst
(North Dakota State University, 2018)
Organocatalysis is a field that has bloomed over the last decades. With the field’s promise of being able to mimic nature and afford products in a synergistic manner to traditional Lewis acid catalysis, several interesting ...