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Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling Reaction of Aromatic Esters and Aromatic Diesters with Arylboronic Acids
(North Dakota State University, 2020)
The palladium-catalyzed cross-coupling reactions for the functionalization of the ester bond provides a significant overall improvement in the catalytic system as compared to aryl halides/pseudo-halides electrophilic ...
VIP Induces Snail1, A Master EMT Regulator: Upregulation in A375 Cancer Cells
(North Dakota State University, 2021)
VIP is neurotransmitter with pleiotropic functions in mammals. It is expressed by a large number of tissues, including the CNS, PNS, innate and adaptive immune systems. VIP has two endogenous G-protein coupled receptors, ...
A Metal Catalyzed Approach for Heterocycle Coupling Reactions
(North Dakota State University, 2021)
Heterocycles are cyclic compounds which contain atoms from at least two different elements. The work in this thesis describes methods we developed for the direct chemical transformation of indole heterocycles with various ...
Novel Synthetic Routes to Complex Amines: the Catalytic Hydroamination of Alkynes and Hydroimination of Allenes
(North Dakota State University, 2016)
Amines are valuable targets for synthesis in contexts of both research and industrial applications. This work proposes two atom-economical methods—hydroamination (HAM) and hydroimination (HIM)—as C-N bond formation strategies. ...
Carbon Nanotubes-Based Lateral Flow Biosensor for Sensitive and Rapid Detection of DNA Sequence
(North Dakota State University, 2017)
Sensitive detection for DNA has drawn great attention in plenty of different areas such as genetics therapy and basic discovery research. Recently, nucleic acid lateral flow biosensor (NALFB) has gained considerable attention ...
Supramolecular Functionalization of Single-Walled Carbon Nanotubes
(North Dakota State University, 2013)
Single-walled carbon nanotubes (SWNTs) possess extraordinary mechanical strength, thermal and electrical conductivity. These properties make them very attractive in many applications in the fields of nanotechnology, ...
Characterizing the Roles of Exit Tunnel Residues in Ligand Binding and Catalysis of Histone Deacetylase-8
(North Dakota State University, 2014)
Histone deacetylases are an important class of enzymes that catalyze the hydrolysis of acetyl-L-lysine side chains in histone and non-histone proteins to yield L-lysine and acetate, effecting the epigenetic regulation of ...
Synthesis and Applications of Dialdehydes
(North Dakota State University, 2018)
Due to their reactivity and ease of functional group interconversions, aldehydes have wide-ranging applications in polymer synthesis, such as polyacetals, epoxy resins, and polyurethanes. Recently, room temperature synthesis ...
Identification of Aptamer Specific for Carcinoembryonic Antigen and its Analytical Applications
(North Dakota State University, 2017)
Carcinoembryonic Antigen (CEA) is an approved cancer biomarker by the Food and Drug Administration (FDA) for the early detection, diagnosis, and for the use in the regular screening of patients at high risk for the development ...
Identification of Novel RPA-Protein Interactions Using the Yeast Two Hybrid Assay and Identification of Regions Important for Interaction Between RPA and Rad24
(North Dakota State University, 2013)
Replication Protein A (RPA) [Replication Factor A (RFA) in yeast] is an ssDNA binding protein
composed of Rpa1, Rpa2, and Rpa3 and involved in numerous DNA processing pathways such as
Replication, Recombination, and Repair. ...