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Biochemical and Cellular Characterization of Replication Factor A (RFA) During Meiosis and The DNA Damage Response in Saccharomyces cerevisiae
(North Dakota State University, 2021)
Replication Factor A (RFA) is an essential heterotrimeric single-stranded DNA (ssDNA) binding complex, comprised of Rfa1, Rfa2, and Rfa3 in Saccharomyces cerevisiae. RFA is required for DNA replication, repair, recombination, ...
The Biology of the Receptor for Advanced Glycation End Products (RAGE) in Cancer
(North Dakota State University, 2020)
Overexpression of the Receptor for Advanced Glycation End Products (RAGE) has been implicated in multiple diseases, including several types of cancer. In different types of cancer, RAGE has been shown to promote cell ...
Changing the Pancreatic Cancer Treatment Paradigm: Developing Clostridium novyi as an Intravenously Injectable Solid-State Tumor Therapeutic
(North Dakota State University, 2020)
The development of a drug able to distinguish between tumor and host cells has been long sought, but the solid tumor microenvironment (TME) confounds many current therapeutics. Solid tumors present several challenges for ...
Factors Affecting Metabolism During Non-Feeding Stages in Insects
(North Dakota State University, 2020)
Although feeding is important for optimal development and growth in insects, there are several points during the insect life cycle that are non-feeding: metamorphosis, pupation, and overwintering. Non-feeding periods also ...
Therapeutic Potential of Piperlongumine for Pancreatic Ductal Adenocarcinoma
(North Dakota State University, 2019)
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal malignancies because it is often diagnosed at a late disease stage and has a poor response rate to currently available treatments. Therefore, it is critical ...
Regulation of Insulin- and Insulin Receptor-Encoding mRNAS in Rainbow Trout, Oncorhynchus Mykiss
(North Dakota State University, 2012)
In this work, rainbow trout were used as a model system to examine the regulation of insulin (INS)- and insulin receptor (IR)-encoding mRNA expression profiles. INS- and IR-encoding mRNAs were isolated, cloned, and sequenced; ...
Effects of Environmental Estrogens on the Growth Hormone-Insulin-Like Growth Factor System in Rainbow Trout (Oncorhynchus Mykiss)
(North Dakota State University, 2013)
The increasing production, use, and disposal of an expanding array of chemicals that enter the environment pose a serious threat to terrestrial and aquatic animals, as well as to humans. Fish in aquatic habitats are exposed ...
Nos1-Adaptor Protein Dysfunction in the Nucleus Tractus Solitarii Contributes to the Neurogenic Heart Damage and Qt Interval Prolongation
(North Dakota State University, 2015)
Variants of the Nitric Oxide Synthase 1 Adaptor Protein (NOS1AP) locus are strongly related to QT interval prolongation and sudden cardiac death (SCD) in human. Neurogenic cardiac damage due to subarachnoid hemorrhage, ...
Anticancer Mechanisms of Flaxseed and its Derived Mammalian Lignan Enterolactone in Lung
(North Dakota State University, 2017)
Whole flaxseed and its derived lignans have shown anti-cancer properties in a variety of malignancies. However, their potential remains uninvestigated in lung cancer, the leading cause of cancer-related deaths worldwide. ...
Mechanisms of Piperlongumine-Induced Cancer Cell Death
(North Dakota State University, 2015)
Piperlongumine (PPLGM), a bioactive agent obtained from long pepper plants, possesses
potent antitumor activity by inducing reactive oxygen species (ROS). However, the mechanisms
for PPLGM’s antitumor actions are not well ...