Cellular & Molecular Biology Doctoral Work
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Glutathione S-Transferase Pi-1 in Pancreatic Cancer Pathogenesis: Mechanistic Insights Into Its Role in Oxidative Stress, Cell Signaling, and Metabolic Pathways
(North Dakota State University, 2021)Pancreatic ductal adenocarcinoma (PDAC) is currently the third leading cause of cancer-related deaths in the US. Although surgery remains the most effective treatment option, only a few PDACs are resectable at diagnosis. ... -
Biochemical and Cellular Characterization of Replication Factor A (RFA) During Meiosis and The DNA Damage Response in Saccharomyces cerevisiae
(North Dakota State University, 2021)Replication Factor A (RFA) is an essential heterotrimeric single-stranded DNA (ssDNA) binding complex, comprised of Rfa1, Rfa2, and Rfa3 in Saccharomyces cerevisiae. RFA is required for DNA replication, repair, recombination, ... -
Changing the Pancreatic Cancer Treatment Paradigm: Developing Clostridium novyi as an Intravenously Injectable Solid-State Tumor Therapeutic
(North Dakota State University, 2020)The development of a drug able to distinguish between tumor and host cells has been long sought, but the solid tumor microenvironment (TME) confounds many current therapeutics. Solid tumors present several challenges for ... -
Factors Affecting Metabolism During Non-Feeding Stages in Insects
(North Dakota State University, 2020)Although feeding is important for optimal development and growth in insects, there are several points during the insect life cycle that are non-feeding: metamorphosis, pupation, and overwintering. Non-feeding periods also ... -
The Biology of the Receptor for Advanced Glycation End Products (RAGE) in Cancer
(North Dakota State University, 2020)Overexpression of the Receptor for Advanced Glycation End Products (RAGE) has been implicated in multiple diseases, including several types of cancer. In different types of cancer, RAGE has been shown to promote cell ... -
Therapeutic Potential of Piperlongumine for Pancreatic Ductal Adenocarcinoma
(North Dakota State University, 2019)Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal malignancies because it is often diagnosed at a late disease stage and has a poor response rate to currently available treatments. Therefore, it is critical ... -
Structural Studies of BECN1, A Key Autophagy Protein, and Intrinsically Disordered Regions in Autophagy Proteins
(North Dakota State University, 2016)Autophagy, a conserved catabolic process required for cellular homeostasis in eukaryotes, is regulated by many proteins. The central goal of my doctoral research is to investigate conformational flexibility of autophagy ... -
The Discovery of a Novel Growth Hormone Receptor and the Nutritional Regulation of the Growth Related Actions of Growth Hormone
(North Dakota State University, 2017)The growth hormone (GH) family peptides such as GH, prolactin (PRL), and somatolactin (SL) regulate a wide array of physiological actions including but not limited to growth, metabolism, osmoregulation, and lipolysis. These ... -
Nutritional Regulation of Growth Hormone-Stimulated Lipolysis
(North Dakota State University, 2014)Growth hormone (GH) regulates several physiologic processes in vertebrates, including the promotion of growth, an anabolic process, and mobilization of stored lipid, a catabolic process. Here, we used rainbow trout ... -
Nos1-Adaptor Protein Dysfunction in the Nucleus Tractus Solitarii Contributes to the Neurogenic Heart Damage and Qt Interval Prolongation
(North Dakota State University, 2015)Variants of the Nitric Oxide Synthase 1 Adaptor Protein (NOS1AP) locus are strongly related to QT interval prolongation and sudden cardiac death (SCD) in human. Neurogenic cardiac damage due to subarachnoid hemorrhage, ... -
Effects of Environmental Estrogens on the Growth Hormone-Insulin-Like Growth Factor System in Rainbow Trout (Oncorhynchus Mykiss)
(North Dakota State University, 2013)The increasing production, use, and disposal of an expanding array of chemicals that enter the environment pose a serious threat to terrestrial and aquatic animals, as well as to humans. Fish in aquatic habitats are exposed ... -
Augmented Expression of Apelin/APJ in the Paraventricular Nuclei of Rats after Myocardial Infarction
(North Dakota State University, 2012)Heart failure (HF) is a disease condition in which insufficient blood is pumped through the body. The pathophysiology of HF is multisystematic and includes a collection of different responses to compensate for the inability ... -
Immunomodulatory Role of B Lymphocytes and Hyaluronic Acid in a Murine Model of Allergic Asthma
(North Dakota State University, 2012)In the world today, asthma affects more than 235 million people. The widespread prescription of inhaled corticosteroids—the current gold standard of asthma control medication—allows many asthmatics to live symptom-free and ... -
The Role of Platelet-Derived Growth Factor Receptor Signaling in Medulloblastoma Metastasis
(North Dakota State University, 2013)Medulloblastoma is the most common brain tumor in children and one third of the patients remain incurable. Tumor metastasis is one of the primary reasons for its high mortality rate. Despite evidence of overexpression of ... -
Regulation of Insulin- and Insulin Receptor-Encoding mRNAS in Rainbow Trout, Oncorhynchus Mykiss
(North Dakota State University, 2012)In this work, rainbow trout were used as a model system to examine the regulation of insulin (INS)- and insulin receptor (IR)-encoding mRNA expression profiles. INS- and IR-encoding mRNAs were isolated, cloned, and sequenced; ... -
Anticancer Mechanisms of Flaxseed and its Derived Mammalian Lignan Enterolactone in Lung
(North Dakota State University, 2017)Whole flaxseed and its derived lignans have shown anti-cancer properties in a variety of malignancies. However, their potential remains uninvestigated in lung cancer, the leading cause of cancer-related deaths worldwide. ... -
Mechanisms of Piperlongumine-Induced Cancer Cell Death
(North Dakota State University, 2015)Piperlongumine (PPLGM), a bioactive agent obtained from long pepper plants, possesses potent antitumor activity by inducing reactive oxygen species (ROS). However, the mechanisms for PPLGM’s antitumor actions are not well ...
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