Two experiments were conducted to detect differences in growth and cold hardiness during establishment of northern grown wine grapevines. One experiment tested the use of four grow tube treatments and two pruning levels on vine establishment in the upper Midwest. The variables included leaf area, stem height, root growth, phenology, and hardiness. Overall, few significant differences occurred among treatments where grow tubes were utilized. In the second season, vines without grow tubes had superior measurements in nearly all leaf area categories. For this reason, it is recommended that growers refrain from grow tube use during establishment in northern growing regions. Vines pruned to three buds after transplanting varied little from those without pruning. For this reason, it is recommended that growers utilize the most efficient early pruning strategy for their particular situation. Another experiment was conducted to determine the effectiveness of different weed control measures. This experiment compared three kinds of mulches and an herbicide treatment on the growth and establishment of four wine grape varieties. Annual weed control, plant growth, phenology, soil water content and temperature, and vine hardiness were measured. Overall, vines receiving mulch had more consistent annual weed control and reduced early season growth when compared to chemically treated vines. For this reason, mulch is recommended in the vineyard for annual weed control during establishment in situations where vigor is not unacceptably low.