In the northeastern United States, craft beer is on the rise. With local brewing increasing, the supply of local raw materials becoming an urgent problem in some northeastern states, like Michigan, New York, Ohio, Pennsylvania, and Vermont. The overall goal of the project is to determine which cultivars are best adapted to specific regions in the northeastern United States, and to detect the impact of different environment factors on the barley genotypes. In general, cultivars from Europe had better resistance to pre-harvest sprouting (PHS) and lower beta-glucan levels than two-rowed cultivars developed in North America. The varieties, Explorer, LCS Genie, LCS Odyssey, KWS Fantex, and KWS Beckie are candidates for production in the eastern United States because of their higher levels of resistance to PHS and malt extract, and their lowers levels of beta-glucan.