Experiments evaluated sugarbeet tolerance, herbicide efficacy on common lambsquarters (Chenopodium album L.), redroot pigweed (Amaranthus retroflexus L.) and waterhemp (Amaranthus tuberculatus (moq.) J.D. Sauer), and rotational crop safety to ethofumesate (2-Ethoxy-2,3-dihydro-3,3-dimethyl-5-benzofuranol methanesulfonate) in 2017, 2018, and 2019. Ethofumesate applied at 2.24 or 4.48 kg ha-1 at the sugarbeet two-true leaf stage reduced sugarbeet stature and recoverable sucrose in field experiments. Ethofumesate at 1.12 kg ha-1 plus glyphosate at 1.26 kg ha-1 applied preemergence (PRE) or early postemergence (EPOST) to 1.3-cm weeds provided broad spectrum control with the least sugarbeet stature reduction in field and greenhouse experiments. Corn (Zea mays L.), dry bean (Phaseolus vulgaris L.), soybean (Glycine max L.), and wheat (Triticum aestivum L.) stand density, stature reduction, flowering date, grain yield, test weight, and grain moisture were not affected by 4.48 kg ha-1 ethofumesate applied at calendar dates representing 9-, 10-, and 11-month intervals between sugarbeet and rotational crops.