Browsing Pharmacy Doctoral Work by Title
Now showing items 29-48 of 51
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GLUT-1 Targeted Gene Delivery to Brain for the Treatment of Alzheimer's Disease
(North Dakota State University, 2021)Alzheimer’s disease (AD) is a neurodegenerative disorder resulting in debilitating dementia with progressive loss of motor functions. Genetic modulation of neurotrophic factors and apolipoprotein E (ApoE) have emerged as ... -
Hypoxic Regulation of Angiotensin-Converting Enzyme 2 and Mas Receptor in Hematopoietic Stem/Progenitor Cells: A Translational Study
(North Dakota State University, 2019)Vascular disease is the leading cause of mortality and morbidity in the western world, and account for the 1 of every 3 death’s in the US, but a cure for vascular disease is yet to be realized. Hematopoietic stem progenitor ... -
Identification and Characterization of Binding Target Proteins of Cancer Stem Cell Inhibitor Salinomycin in Human Neuroblastoma
(North Dakota State University, 2015)Salinomycin, a widely used anti-coccidial agent, was recently identified as a cancer stem cell (CSC) inhibitor from a library of 16,000 natural and commercial chemical compounds based on its highly selective inhibitory ... -
In Vitro Detection of Disease Biomarkers and Drug Contaminants
(North Dakota State University, 2013)In recent years the rising cost and increased regulation within the U.S. healthcare system have caused medical laboratory tests to become more costly and more frequently required. As a result, insurance premiums are rising, ... -
Inhibition of Nitric Oxide Signaling by Melatonin in Porcine Coronary Arteries
(North Dakota State University, 2012)This research represents an effort to bridge a critical gap in the understanding of the local effects of melatonin on the coronary circulation. The first objective was designed to identify the specific melatonin receptor ... -
Interactions of the Receptor for Advanced Glycation End Products (Rage) with Advanced Glycation End Products (AGEs) and S100B
(North Dakota State University, 2016)RAGE is a multi-ligand pattern recognition receptor. RAGE can bind several damage associated molecular pattern proteins. RAGE- ligand interaction is pathophysiologically relevant to several major diseases including diabetes ... -
Kisspeptins: Airway Remodeling in Asthma
(North Dakota State University, 2022)Asthma is a chronic respiratory disorder that affects people of all ages. Sex and gender disparity in asthma is recognized and suggests a modulatory role for sex steroids, particularly estrogen. However, there is a dichotomous ... -
Knockdown of Delta-5 Desaturase to Elicit Anti-Cancer Effect of Dihomo-γ-Linolenic Acid: Development of an ω-6 Fatty Acid-Based Therapeutic Strategy for Pancreatic Cancer
(North Dakota State University, 2017)Pancreatic cancer is one of the most common causes of cancer death in the United States. Unlike ω-3 fatty acids, which have been commonly used as complementary therapy to treat pancreatic cancer, ω-6s (more abundant fatty ... -
Mir-627 Mediates the Epignetic Mechanisms of Vitamin D in Suppression of Colon Cancer Growth
(North Dakota State University, 2013)Low circulating vitamin D levels have been linked to increased risks of cancer by epidemiologic studies, and preclinical research has demonstrated clear antitumor activities of vitamin D against various types of cancers. ... -
Modifications of Recombinant Spider Silk Protein for Various Biomedical Applications
(North Dakota State University, 2020)Silk is a natural protein produced by members of the class Arachnida (over 30,000 species of spiders) and by several worms. Silk-based materials have been investigated for medical and biotechnological applications for many ... -
A Nano-Sized Approach to Exploiting the Pancreatic Tumor Microenvironment
(North Dakota State University, 2020)Making up just over 3% of all new cancer cases in the United States, pancreatic cancer is not inherently a common malignant disease. Yet, it continuously is shown to be one of the most lethal and common causes of cancer ... -
The Potential Inhibitory Effect of Dihomo-Gamma-Linolenic Acid on Colon Cancer Cell Growth via Free Radical Metabolites in Cyclooxygenase-Catalyzed Peroxidation
(North Dakota State University, 2012)Cyclooxygenase (COX) can metabolize dihomo-γ-linolenic acid (DGLA) and arachidonic acid (AA) through free radical-mediated lipid peroxidation to form the anti-carcinogenic 1-series of prostaglandins and pro-carcinogenic ... -
Rage (Receptor for Advanced Glycation End Products) in Melanoma Progression
(North Dakota State University, 2014)The Receptor for Advanced Glycation End Products (RAGE) and its ligands are expressed in multiple cancer types and are implicated in cancer progression. Our lab has previously reported higher transcript levels of RAGE and ... -
Regulation of Vascular Tone in Cerebral and Coronary Arteries by Apelin/APJ Receptor Mechanisms
(North Dakota State University, 2018)The peptide, apelin, is expressed in fat cells, endothelial cells, and CNS neurons. Increasing evidence (e.g. inotropic and vasomotor effects) supports a role for apelin in the regulation of the cardiovascular system. This ... -
Role of Large Conductance, Calcium-Activated Potassium Channels (BKCa) in Vasorelaxation of Nitrate Tolerant Mesenteric Arteries
(North Dakota State University, 2016)Video summarizing Ph.D. dissertation for a non-specialist audience. -
The Role of the Gut Microbiota in Sustained Weight Loss Following Roux-en-Y Gastric Bypass Surgery
(North Dakota State University, 2018)Roux-en-Y Gastric Bypass (RYGB) surgery is one of the most effective approaches for the treatment of severe obesity. Despite substantial weight loss following RYGB, a considerable proportion of patients experience weight ... -
Smart, Biocompatible Polymersomes for Targeted Delivery of Therapeutic Agents to Cancerous Tumors
(North Dakota State University, 2017)Chemotherapeutics are the major treatment options for cancer. Although we cannot underestimate the importance of the chemotherapeutic drugs, their systemic toxicity is an important limiting factor for their use. Therefore, ... -
Synthesis and Evaluation of Cationic Nanomicelles for In Vitro and In Vivo Gene Delivery
(North Dakota State University, 2013)The goal of proposed study was to contribute towards the development of a nano size, high efficiency and low toxicity non-viral polymeric vector for gene delivery in vitro and in vivo. A series of fatty acid grafted ... -
Targeted Stimuli-Responsive Carriers for Efficient Delivery of Chemotherapeutic Drugs
(North Dakota State University, 2017)Chemotherapeutic agents for treating various cancers show considerable side effects and toxicity. Often cancer relapses after initial response to the chemotherapy. Tumor cells are heterogeneous and have the progenitor stem ... -
Targeted Three-Way-Junction RNA Nanoparticle Reprogrammed Cyclooxygenase-2 Catalyzed Dihomo-ϒ-Linolenic Acid Peroxidation Pattern in Lung Cancer
(North Dakota State University, 2021)As the second most common cancer and the first leading cause of cancer deaths, lung cancer attracts much research attention. Since cyclooxygenase-2 (COX-2) is overexpressing in nearly 80% of lung cancer patients, COX-2 ...