Browsing Pharmacy Doctoral Work by Issue Date
Now showing items 1-20 of 51
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Effect of Dietary Omega-3 and Omega-6 Polyunsaturated Fatty Acids on Alcoholic Liver Disease
(North Dakota State University, 2012)PUFAs have been shown to modulate ALD by several mechanisms, including free radical generation from hepatic lipid peroxidation. However, how they modulate lipid peroxidation and generation of bioactive metabolites in ALD ... -
Fluorescent Polymer Based Post-Translational Differentiation and Subtyping of Cancer Cells
(North Dakota State University, 2012)The field of personalized medicine is focused on gathering information at a pre-translational level. Although this information is useful, it is becoming increasingly apparent that post-translational expression is not always ... -
Inhibition of Nitric Oxide Signaling by Melatonin in Porcine Coronary Arteries
(North Dakota State University, 2012)This research represents an effort to bridge a critical gap in the understanding of the local effects of melatonin on the coronary circulation. The first objective was designed to identify the specific melatonin receptor ... -
The Potential Inhibitory Effect of Dihomo-Gamma-Linolenic Acid on Colon Cancer Cell Growth via Free Radical Metabolites in Cyclooxygenase-Catalyzed Peroxidation
(North Dakota State University, 2012)Cyclooxygenase (COX) can metabolize dihomo-γ-linolenic acid (DGLA) and arachidonic acid (AA) through free radical-mediated lipid peroxidation to form the anti-carcinogenic 1-series of prostaglandins and pro-carcinogenic ... -
Detection of Metalloenzymes Employing Fluorescentpolymers and Liposomes
(North Dakota State University, 2012)In the biological systems, proteins are important constituents. Protein-protein interactions play vital roles in physiological environments and any disruption in these interactions lead to adverse effects. However, designing ... -
Design and Synthesis of Peptide-Based Nanofibers for Imaging and Therapy of Cancer
(North Dakota State University, 2013)Nanotechnology has been the subject of significant scientific and biomedical development efforts over the past decades. Improvement in biomarker discovery, targeting approaches and conjugation chemistries has led to the ... -
Controlled Delivery of Basal Level of Insulin
(North Dakota State University, 2013)The present study was aimed at developing a delivery system for controlled release of insulin at basal level from chitosan-zinc-insulin complex incorporated into thermosensitive polymer, poly(lactic acid)-poly(ethylene ... -
In Vitro Detection of Disease Biomarkers and Drug Contaminants
(North Dakota State University, 2013)In recent years the rising cost and increased regulation within the U.S. healthcare system have caused medical laboratory tests to become more costly and more frequently required. As a result, insurance premiums are rising, ... -
Angiotensin (1-7) Attenuates the Chronotropic Response to Angiotensin II via Stimulation of PTEN in Spontaneously Hypertensive Rat Brain
(North Dakota State University, 2013)The pathogenesis of hypertension and its mode of progression are complex, multifactorial and incompletely understood. Several studies have focused on the beneficial effects of peripheral Ang (1-7) in the regulation of ... -
Synthesis and Evaluation of Cationic Nanomicelles for In Vitro and In Vivo Gene Delivery
(North Dakota State University, 2013)The goal of proposed study was to contribute towards the development of a nano size, high efficiency and low toxicity non-viral polymeric vector for gene delivery in vitro and in vivo. A series of fatty acid grafted ... -
Development of New Antibody Based Theranostic Agents Targeting the Receptor for Advanced Glycation End-Product (Rage)
(North Dakota State University, 2013)The Receptor for Advanced Glycation End products (RAGE) interacts with several classes of structurally unrelated ligands. The activation of RAGE by its ligands results in the cellular activation of several kinases and ... -
Mir-627 Mediates the Epignetic Mechanisms of Vitamin D in Suppression of Colon Cancer Growth
(North Dakota State University, 2013)Low circulating vitamin D levels have been linked to increased risks of cancer by epidemiologic studies, and preclinical research has demonstrated clear antitumor activities of vitamin D against various types of cancers. ... -
Rage (Receptor for Advanced Glycation End Products) in Melanoma Progression
(North Dakota State University, 2014)The Receptor for Advanced Glycation End Products (RAGE) and its ligands are expressed in multiple cancer types and are implicated in cancer progression. Our lab has previously reported higher transcript levels of RAGE and ... -
Evaluation of Hydrophobically Modified Low Molecular Weight Chitosan as a Potential Nonviral Vector for DND Vaccine Delivery
(North Dakota State University, 2014)Gene therapy has great potential in disease prevention and treatment. The purpose of the proposed research was to advance the development of safe and effective nonviral polymeric vectors for targeted gene therapy and DNA ... -
Design and Evaluation of Polymeric Nanomaterials for In Vitro and In Vivo Imaging Applications
(North Dakota State University, 2014)One of the most versatile and safe material used in medicine is polymer-based nanomaterials. This dissertation describes the use of several formulations of polymeric nanomaterials for in vitro and in vivo optical imaging ... -
Dual Modified Liposomes for Drug and Gene Delivery to Brain
(North Dakota State University, 2014)The overall goal of our research was to design a vector for efficient delivery of therapeutic genes/drugs to brain. Specifically, this research work was focused on designing PEGylated liposomes surface modified with the ... -
Development and Characterization of Multifunctional Nanoparticles for Drug Delivery to Cancer Cells
(North Dakota State University, 2014)Lipid and polymeric nanoparticles, although proven to be effective drug delivery systems compared to free drugs, have shown considerable limitations pertaining to their uptake and release at tumor sites. Spatial and temporal ... -
Identification and Characterization of Binding Target Proteins of Cancer Stem Cell Inhibitor Salinomycin in Human Neuroblastoma
(North Dakota State University, 2015)Salinomycin, a widely used anti-coccidial agent, was recently identified as a cancer stem cell (CSC) inhibitor from a library of 16,000 natural and commercial chemical compounds based on its highly selective inhibitory ... -
Epigenetic Regulation of Apoptosis in Prostate Cancer
(North Dakota State University, 2015)Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the polycomb repressive complex 2 and suppresses gene expression by catalyzing histone H3 methylation on lysine 27. EZH2 is overexpressed in metastatic ... -
Design and Development of Tumor Microenvironment Responsive PEGylated Nanoparticles for Drug Delivery to Cancerous Solid Tumors
(North Dakota State University, 2016)Rapid growth of cancerous cells creates a biochemically distinct microenvironment in solid tumors. Leaky vasculature, lower pH, increased levels of proteolytic enzymes, hypoxia serve as hallmarks of tumor tissues. These ...