Browsing Pharmacy Doctoral Work by Issue Date
Now showing items 21-40 of 51
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Role of Large Conductance, Calcium-Activated Potassium Channels (BKCa) in Vasorelaxation of Nitrate Tolerant Mesenteric Arteries
(North Dakota State University, 2016)Video summarizing Ph.D. dissertation for a non-specialist audience. -
Interactions of the Receptor for Advanced Glycation End Products (Rage) with Advanced Glycation End Products (AGEs) and S100B
(North Dakota State University, 2016)RAGE is a multi-ligand pattern recognition receptor. RAGE can bind several damage associated molecular pattern proteins. RAGE- ligand interaction is pathophysiologically relevant to several major diseases including diabetes ... -
Development of a Novel Omega-6 Fatty Acid Based Treatment Strategy for Colon Cancer by Knocking Down Delta-5-Desaturase and Exploiting High COX-2 Levels in Cancer CellsTumors
(North Dakota State University, 2017)Colon cancer is the third most commonly diagnosed cancer in the world. Research showed that arachidonic acid, a downstream ω-6 fatty acid (ω-6), plays a role in colon cancer development by producing deleterious metabolites ... -
Angiotensin-(1-7): A Target for Stem Cell Mobilopathy and Vascular Repair in Diabetes
(North Dakota State University, 2017)Bone marrow stem/progenitor cells (BMPCs) accelerate vascular repair by re-endothelialization and revascularization of ischemic areas. Diabetes causes impairment of BMPC mobilization, a.k.a. stem cell mobilopathy, and ... -
Targeted Stimuli-Responsive Carriers for Efficient Delivery of Chemotherapeutic Drugs
(North Dakota State University, 2017)Chemotherapeutic agents for treating various cancers show considerable side effects and toxicity. Often cancer relapses after initial response to the chemotherapy. Tumor cells are heterogeneous and have the progenitor stem ... -
Knockdown of Delta-5 Desaturase to Elicit Anti-Cancer Effect of Dihomo-γ-Linolenic Acid: Development of an ω-6 Fatty Acid-Based Therapeutic Strategy for Pancreatic Cancer
(North Dakota State University, 2017)Pancreatic cancer is one of the most common causes of cancer death in the United States. Unlike ω-3 fatty acids, which have been commonly used as complementary therapy to treat pancreatic cancer, ω-6s (more abundant fatty ... -
Elicit Anti-Cancer Effects of Dihomo-γ-linolenic Acid by Exploiting Overexpressed COX-2 in Cancer: Development of an ω-6 Fatty Acid-Based Therapeutic Strategy for Pancreatic Cancer
(North Dakota State University, 2017)Video summarizing Ph.D. dissertation for a non-specialist audience. -
Smart, Biocompatible Polymersomes for Targeted Delivery of Therapeutic Agents to Cancerous Tumors
(North Dakota State University, 2017)Chemotherapeutics are the major treatment options for cancer. Although we cannot underestimate the importance of the chemotherapeutic drugs, their systemic toxicity is an important limiting factor for their use. Therefore, ... -
Ang II-Induced Cardiac Remodeling: Role of PI3-Kinase-Dependent Autophagy
(North Dakota State University, 2018)Heart failure (HF) is a pathological state indicating insufficient blood supply to the peripheral tissues from the heart. The pathophysiology of HF is multifactorial like cardiac remodeling including cardiac hypertrophy, ... -
Regulation of Vascular Tone in Cerebral and Coronary Arteries by Apelin/APJ Receptor Mechanisms
(North Dakota State University, 2018)The peptide, apelin, is expressed in fat cells, endothelial cells, and CNS neurons. Increasing evidence (e.g. inotropic and vasomotor effects) supports a role for apelin in the regulation of the cardiovascular system. This ... -
The Role of the Gut Microbiota in Sustained Weight Loss Following Roux-en-Y Gastric Bypass Surgery
(North Dakota State University, 2018)Roux-en-Y Gastric Bypass (RYGB) surgery is one of the most effective approaches for the treatment of severe obesity. Despite substantial weight loss following RYGB, a considerable proportion of patients experience weight ... -
Evaluation of Smart Polymers for Controlled Release Delivery Systems
(North Dakota State University, 2019)Our goal was to develop a smart polymer, controlled release delivery system and evaluate its capabilities for use with salmon calcitonin and rivastigmine. Thermosensitive and phase sensitive smart polymers were evaluated ... -
Hypoxic Regulation of Angiotensin-Converting Enzyme 2 and Mas Receptor in Hematopoietic Stem/Progenitor Cells: A Translational Study
(North Dakota State University, 2019)Vascular disease is the leading cause of mortality and morbidity in the western world, and account for the 1 of every 3 death’s in the US, but a cure for vascular disease is yet to be realized. Hematopoietic stem progenitor ... -
Dual Functionalized Liposomes for Co-delivery of Anti-cancer Chemotherapeutics for Treatment of Brain Tumor
(North Dakota State University, 2019)Glioblastoma is a hostile brain tumor associated with high infiltration leading to poor prognosis. Currently available treatment options are insufficient to increase median survival time. The combination therapy has emerged ... -
Drug Delivery Systems for Treatment of Diabetes Mellitus
(North Dakota State University, 2019)Daily injections for basal insulin therapy are far from ideal resulting in hypo/hyperglycemic episodes associated with fatal complications in type-1 diabetes patients. The purpose of this study was to develop a thermosensitive ... -
Understanding the Role of the Receptor for Advanced Glycation End-Products (Rage) in Pancreatic Cancer
(North Dakota State University, 2019)Expression of the Receptor for Advanced Glycation End Products (RAGE) and is upregulated in a several cancers. Based on published studies, we hypothesized that RAGE, when overexpressed in pancreatic cancer cells, will ... -
Dual-Functionalized Liposomes for Gene Delivery to Brain to Prevent and Treat Alzheimer’s Disease
(North Dakota State University, 2019)Alzheimer’s disease (AD) is the most common age-related neurodegenerative disorder which lacks effective disease-modifying therapies. We have investigated the therapeutic potential of pDNA encoding apolipoprotein E2 (ApoE2), ... -
A Nano-Sized Approach to Exploiting the Pancreatic Tumor Microenvironment
(North Dakota State University, 2020)Making up just over 3% of all new cancer cases in the United States, pancreatic cancer is not inherently a common malignant disease. Yet, it continuously is shown to be one of the most lethal and common causes of cancer ... -
Modifications of Recombinant Spider Silk Protein for Various Biomedical Applications
(North Dakota State University, 2020)Silk is a natural protein produced by members of the class Arachnida (over 30,000 species of spiders) and by several worms. Silk-based materials have been investigated for medical and biotechnological applications for many ... -
Antibiotic Releasing Bone-Void Filler for the Treatment of Osteomyelitis: An Approach to Treat Infection and Aid Bone Regeneration
(North Dakota State University, 2020)Osteomyelitis or bone infections remain very difficult to treat despite advances in treatment regimens and surgical technics. The bone microenvironment and compromised vasculature in addition to infected prosthesis and ...