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Evaluation of Smart Polymers for Controlled Release Delivery Systems
(North Dakota State University, 2019)
Our goal was to develop a smart polymer, controlled release delivery system and evaluate its capabilities for use with salmon calcitonin and rivastigmine. Thermosensitive and phase sensitive smart polymers were evaluated ...
Effect of Dietary Omega-3 and Omega-6 Polyunsaturated Fatty Acids on Alcoholic Liver Disease
(North Dakota State University, 2012)
PUFAs have been shown to modulate ALD by several mechanisms, including free radical generation from hepatic lipid peroxidation. However, how they modulate lipid peroxidation and generation of bioactive metabolites in ALD ...
Design and Development of Tumor Microenvironment Responsive PEGylated Nanoparticles for Drug Delivery to Cancerous Solid Tumors
(North Dakota State University, 2016)
Rapid growth of cancerous cells creates a biochemically distinct microenvironment in solid tumors. Leaky vasculature, lower pH, increased levels of proteolytic enzymes, hypoxia serve as hallmarks of tumor tissues. These ...
Rage (Receptor for Advanced Glycation End Products) in Melanoma Progression
(North Dakota State University, 2014)
The Receptor for Advanced Glycation End Products (RAGE) and its ligands are
expressed in multiple cancer types and are implicated in cancer progression. Our lab has
previously reported higher transcript levels of RAGE and ...
Controlled Delivery of Basal Level of Insulin
(North Dakota State University, 2013)
The present study was aimed at developing a delivery system for controlled release of insulin at basal level from chitosan-zinc-insulin complex incorporated into thermosensitive polymer, poly(lactic acid)-poly(ethylene ...
Evaluation of Hydrophobically Modified Low Molecular Weight Chitosan as a Potential Nonviral Vector for DND Vaccine Delivery
(North Dakota State University, 2014)
Gene therapy has great potential in disease prevention and treatment. The purpose of the proposed research was to advance the development of safe and effective nonviral polymeric vectors for targeted gene therapy and DNA ...
Ang II-Induced Cardiac Remodeling: Role of PI3-Kinase-Dependent Autophagy
(North Dakota State University, 2018)
Heart failure (HF) is a pathological state indicating insufficient blood supply to the peripheral tissues from the heart. The pathophysiology of HF is multifactorial like cardiac remodeling including cardiac hypertrophy, ...
Development of a Novel Omega-6 Fatty Acid Based Treatment Strategy for Colon Cancer by Knocking Down Delta-5-Desaturase and Exploiting High COX-2 Levels in Cancer CellsTumors
(North Dakota State University, 2017)
Colon cancer is the third most commonly diagnosed cancer in the world. Research showed that arachidonic acid, a downstream ω-6 fatty acid (ω-6), plays a role in colon cancer development by producing deleterious metabolites ...
In Vitro Detection of Disease Biomarkers and Drug Contaminants
(North Dakota State University, 2013)
In recent years the rising cost and increased regulation within the U.S. healthcare system have caused medical laboratory tests to become more costly and more frequently required. As a result, insurance premiums are rising, ...
Regulation of Vascular Tone in Cerebral and Coronary Arteries by Apelin/APJ Receptor Mechanisms
(North Dakota State University, 2018)
The peptide, apelin, is expressed in fat cells, endothelial cells, and CNS neurons. Increasing evidence (e.g. inotropic and vasomotor effects) supports a role for apelin in the regulation of the cardiovascular system. This ...