Browsing Chemistry & Biochemistry by Title
Now showing items 35-54 of 87
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Influence of Active Site Ligands and Nanoparticle Surfaces on Human Carbonic Anhydrase Isozymes
(North Dakota State University, 2010)Carbonic anhydrase (CA) is an ubiquitously distributed zinc containing metallo enzyme that catalyzes the reversible hydration of carbon dioxide to form bicarbonate and a proton. Existence of 16 isoenzymes of CA in the ... -
Influence of Organic and Inorganic Passivation on the Photophysics of Cadmium Chalcogenide and Lead Chalcogenide Quantum Dots
(North Dakota State University, 2020)Quantum dots (QDs) are promising materials for photovoltaic (PV) and light-emitting diode (LED) applications due to their unique properties: photostability, size-tunable absorptivity, and narrow line-width emission. These ... -
Infrared Diode Laser Spectroscopic Study of Combustion Related Kinetics
(North Dakota State University, 2016)In the introduction section background into the subject of combustion chemistry is presented. The topics included are combustion mechanisms, combustion pollutants, and infrared absorption spectroscopy. Chapter two describes ... -
Interactions of Light with Organic Chromophores: A Photochemical and Photophysical Investigation
(North Dakota State University, 2018)Over the past century, light has emerged as a useful tool finding utility in various fields such as device fabrication, the medical field, as well as utility as an energy source. Chemist have adopted this abundant energy ... -
Interactions of Synthetic Metal Porphyrinates with PhuS, a Cytoplasmic Heme Trafficking Protein from Pseudomonas aeruginosa
(North Dakota State University, 2010)Pseudomonas aeruginosa is an opportunistic, Gram negative, bacterial pathogen that commonly establishes infection in immunocompromised individuals. It contains protein-based, iron uptake pathways that target both heme ... -
Investigating Selected Mechanisms of Modulation of BECN1-mediated Autophagy
(North Dakota State University, 2019)Autophagy is a lysosomal degradation pathway wherein cytoplasmic components not needed by or harmful to the cell are degraded and recycled. BECN homologs are key autophagy proteins consisting of an intrinsically disordered ... -
Investigating the Role of BECN1 Conformationally Flexible Regions and Invariant Cys-x-x-Cys Motifs in Autophagy
(North Dakota State University, 2020)Autophagy is an essential catabolic cellular homeostasis process conserved in all eukaryotes. BECN1, a key autophagy protein involved in autophagosome nucleation, comprises of a large, poorly conserved, N-terminal intrinsically ... -
Late Transition Metal-Catalyst Development for Alkyne Coupling Reactions
(North Dakota State University, 2016)Alkynes are versatile and valuable synthetic precursors in a variety of organic transformations and have found tremendous applications in materials science and pharmaceutical chemistry. In recent years, there has been a ... -
Lateral Flow Nucleic Acid Biosensor for the Detection of Sexually Transmitted Diseases
(North Dakota State University, 2015)Nucleic acid detection is of central importance for the diagnosis and treatment of genetic diseases, infectious agents, bio-warfare agents, and drug discovery. Nucleic acid testing for diseases is exclusively performed in ... -
Ligand Binding and Catalysis in Selected Sirtuin Isozymes
(North Dakota State University, 2016)Due to their intimate roles in survival, longevity as well as pathogenesis via “epigenetic” and “metabolic” regulatory mechanisms, sirtuins have gained considerable interest toward undertaking detailed biochemical/biophysical ... -
Mechanistic Investigation of Catalytic Chlorite Decomposition by Chlorite Dismutase
(North Dakota State University, 2021)Water purification processes often involve chlorine-based disinfectants which consequently leads to formation of chloro oxyanions (ClOx−), potent water-soluble oxidizing agents. These chlorine species are kinetically stable ... -
Mechanistic Studies on the Methionine Aminopeptidase and Peptide Deformylase Catalyzed Reactions
(North Dakota State University, 2013)In the search for novel antibiotic and therapeutic targets, methionine aminopeptidase (MetAP) and peptide deformylase (PDF) have recently been identified as eminently compelling. These enzymes are involved in the ... -
A Metal Catalyzed Approach for Heterocycle Coupling Reactions
(North Dakota State University, 2021)Heterocycles are cyclic compounds which contain atoms from at least two different elements. The work in this thesis describes methods we developed for the direct chemical transformation of indole heterocycles with various ... -
Micro-/Nano- Materials Based Ultrasensitive Lateral Flow Nucleic Acid Biosensors
(North Dakota State University, 2017)Ultrasensitive detection of nucleic acids plays a very important role in the field of molecular diagnosis for the detection of various diseases. Lateral flow biosensors (LFB) are convenient, easy-to-use, patient friendly ... -
New Insights into Apoptosis-Inducing Factor Mediated Pro-Survival Activity
(North Dakota State University, 2022)Cancer is a group of diseases characterized by the uncontrolled growth of cells and is caused by the accumulation of genetic mutations that contribute to cell division, cell growth, and the DNA repair system. According to ... -
New Strategies for Ruthenium Catalyzed C-C Bond Formation
(North Dakota State University, 2014)Transition metal-catalyzed C-H bond activation allows direct functionalization of the ubiquitous C-H bonds in organic molecules to increase the molecular complexity. Since Murai's pioneering work in ruthenium catalyzed ... -
New Strategies for Transition Metal Catalyzed C-C and C-N Bond Formation
(North Dakota State University, 2018)Transition metal catalysis emerged as an essential tool in the field of organic chemistry. In this context, transition metal catalyzed C-H bond functionalization is considered as an alluring strategy as it occurs with the ... -
Novel Asymmetric Approaches for Construction of Small Molecules by Cyclization and Cycloaddition
(North Dakota State University, 2015)Development of novel asymmetric and catalytic methods for synthesizing small organic molecules containing hindered quaternary and tertiary centers is a major challenge and a dynamic area of investigation in synthetic organic ... -
Novel Synthetic Routes to Complex Amines: the Catalytic Hydroamination of Alkynes and Hydroimination of Allenes
(North Dakota State University, 2016)Amines are valuable targets for synthesis in contexts of both research and industrial applications. This work proposes two atom-economical methods—hydroamination (HAM) and hydroimination (HIM)—as C-N bond formation strategies. ... -
The Optimization of Whole Genome Amplification and Molecular Crowding for Use in Forensic Low Copy Number Samples
(North Dakota State University, 2011)Whole genome amplification has been used as a powerful tool to increase the amount of DNA template used for microarrays, STR and SNP assays in clinical and forensic settings. Our laboratory observed that multiple displacement ...