Chemistry & Biochemistry: Recent submissions
Now showing items 1-20 of 90
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Structural Basis of Key Conserved Cell-Surface Signaling Pathways Involved in Iron Import
(North Dakota State University, 2024)Cell surface signaling (CSS) allows Gram-negative bacteria to transcriptionally regulate gene expression in response to external stimuli. CSS pathways involve three key components: an outer membrane transducer for sensing ... -
Investigating the role of BECN2 CCD interactions in canonical and non-canonical autophagy
(North Dakota State University, 2024)Autophagy is a conserved cell-survival pathway wherein old, damaged or harmful cellular components are surrounded by a double membrane vesicle called the autophagosome for lysosomal degradation and recycling. All eukaryotes ... -
Synthesis and Characterization of Thieno[3,4-b]pyrazine-Based Near-Infrared Material
(North Dakota State University, 2024)Since their first report in the 1800s, conjugated polymers have gained significant attention for their ability to exhibit the optical and electronic properties of inorganic semiconductors and the physical traits of organic ... -
Diastereoselective Conjugate Radical Additions to ~-Pyrones
(North Dakota State University, 2009)A convenient protocol for functionalization of ~-pyrones has been developed. Conjugate radical addition and tandem addition-trapping protocols allowed accessing highly substituted pyrones in a single operation with high ... -
Influence of Active Site Ligands and Nanoparticle Surfaces on Human Carbonic Anhydrase Isozymes
(North Dakota State University, 2010)Carbonic anhydrase (CA) is an ubiquitously distributed zinc containing metallo enzyme that catalyzes the reversible hydration of carbon dioxide to form bicarbonate and a proton. Existence of 16 isoenzymes of CA in the ... -
Regioselective and Enantioselective Nitrone Cycloadditions to Alkynones.
(North Dakota State University, 2010)There has been a need in agriculture, medicine, and organic chemistry for enantiopure isoxazolines. A direct method for their synthesis is from the cycloaddition of 1,3-dipoles and alkynes. Alkynones are difficult ... -
Differential Modulation of the Structural and Functional Characteristics of Human Matrix Metalloproteinase Isozymes upon Binding to Different Ligands
(North Dakota State University, 2010)Matrix metalloproteinases (MMPs) are a family of Zn2 + -dependent, Ca2 + -containing endoproteinases involved in tissue remodeling and degradation of the extracellular matrix (ECM). Human MMP isozymes are known to be ... -
Interactions of Synthetic Metal Porphyrinates with PhuS, a Cytoplasmic Heme Trafficking Protein from Pseudomonas aeruginosa
(North Dakota State University, 2010)Pseudomonas aeruginosa is an opportunistic, Gram negative, bacterial pathogen that commonly establishes infection in immunocompromised individuals. It contains protein-based, iron uptake pathways that target both heme ... -
Mechanistic Investigation of Catalytic Chlorite Decomposition by Chlorite Dismutase
(North Dakota State University, 2021)Water purification processes often involve chlorine-based disinfectants which consequently leads to formation of chloro oxyanions (ClOx−), potent water-soluble oxidizing agents. These chlorine species are kinetically stable ... -
Synthesis and Photophysics of Platinum(II) Terdentate and Bidentate Complexes.
(North Dakota State University, 2010)Platinum(ll) terdentate and bidentate complexes possess square-planar d8 configuration. The moderate metal-to-ligand charge-transfer (1MLCT) absorption, 3MLCT emission, and broadband excited-state absorption are the ... -
Synthesis of Novel Biomass-derived Diol and Epoxide Monomers for Coatings Applications
(North Dakota State University, 2022)There are few monomers or precursors in the polymer industry that are more ubiquitous than bisphenol A (BPA). According to the CDC, about 5-6 billion pounds of BPA are produced worldwide annually. For the synthesis of ... -
Examining Thieno[3,4-b]pyrazine Through a Multifaceted Lens: From Extended Ring Functionalization to Ambipolar-Acceptor Copolymers
(North Dakota State University, 2022)A class of materials known as conjugated polymers (CPs) has been shown to integrate the physical properties of organic plastics such as low-weight, flexibility, and synthetic modularity with electronic semiconducting ... -
New Insights into Apoptosis-Inducing Factor Mediated Pro-Survival Activity
(North Dakota State University, 2022)Cancer is a group of diseases characterized by the uncontrolled growth of cells and is caused by the accumulation of genetic mutations that contribute to cell division, cell growth, and the DNA repair system. According to ... -
A Metal Catalyzed Approach for Heterocycle Coupling Reactions
(North Dakota State University, 2021)Heterocycles are cyclic compounds which contain atoms from at least two different elements. The work in this thesis describes methods we developed for the direct chemical transformation of indole heterocycles with various ... -
Scrutinizing the Role of Ambipolar Units in the Donor-Acceptor Framework
(North Dakota State University, 2021)Conjugated polymers (CPs) are a class of materials that contradict what is commonly considered when people hear the terms plastics and electronics. While these two phrases are generally considered exclusive, CPs combine ... -
VIP Induces Snail1, A Master EMT Regulator: Upregulation in A375 Cancer Cells
(North Dakota State University, 2021)VIP is neurotransmitter with pleiotropic functions in mammals. It is expressed by a large number of tissues, including the CNS, PNS, innate and adaptive immune systems. VIP has two endogenous G-protein coupled receptors, ... -
Surface and Interface Effects on the Photoexcited Process of Silver Nanoclusters, and Lead & Cadmium Chalcogenide Nanocrystals
(North Dakota State University, 2020)The surface and interface of the metal nanoclusters and semiconducting nanomaterials play a key role in determining the electronic structure and overall photophysical properties. A single strand DNA stabilizes the metal ... -
Designing Ru Catalysts for Selective C-H Bond Oxidation Reactions
(North Dakota State University, 2020)Typically, C-H bond oxidation proceeds via formation of high-valent metal oxo species. Attaining a high oxidation state of the metal complex is critical as it is the key step for many catalytic processes. Understanding ... -
Investigating the Role of BECN1 Conformationally Flexible Regions and Invariant Cys-x-x-Cys Motifs in Autophagy
(North Dakota State University, 2020)Autophagy is an essential catabolic cellular homeostasis process conserved in all eukaryotes. BECN1, a key autophagy protein involved in autophagosome nucleation, comprises of a large, poorly conserved, N-terminal intrinsically ... -
Enzyme Behavior in Synthetic Materials and Structural Implications for Rational Design
(North Dakota State University, 2020)Combining enzymes with synthetic materials is the new frontier of biocatalysis, materials science, and protein engineering. Enzymes are biological macromolecule catalysts with incredible efficiency and specificity that are ...