Browsing Pharmacy Doctoral Work by Title
Now showing items 35-51 of 51
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Kisspeptins: Airway Remodeling in Asthma
(North Dakota State University, 2022)Asthma is a chronic respiratory disorder that affects people of all ages. Sex and gender disparity in asthma is recognized and suggests a modulatory role for sex steroids, particularly estrogen. However, there is a dichotomous ... -
Knockdown of Delta-5 Desaturase to Elicit Anti-Cancer Effect of Dihomo-γ-Linolenic Acid: Development of an ω-6 Fatty Acid-Based Therapeutic Strategy for Pancreatic Cancer
(North Dakota State University, 2017)Pancreatic cancer is one of the most common causes of cancer death in the United States. Unlike ω-3 fatty acids, which have been commonly used as complementary therapy to treat pancreatic cancer, ω-6s (more abundant fatty ... -
Mir-627 Mediates the Epignetic Mechanisms of Vitamin D in Suppression of Colon Cancer Growth
(North Dakota State University, 2013)Low circulating vitamin D levels have been linked to increased risks of cancer by epidemiologic studies, and preclinical research has demonstrated clear antitumor activities of vitamin D against various types of cancers. ... -
Modifications of Recombinant Spider Silk Protein for Various Biomedical Applications
(North Dakota State University, 2020)Silk is a natural protein produced by members of the class Arachnida (over 30,000 species of spiders) and by several worms. Silk-based materials have been investigated for medical and biotechnological applications for many ... -
A Nano-Sized Approach to Exploiting the Pancreatic Tumor Microenvironment
(North Dakota State University, 2020)Making up just over 3% of all new cancer cases in the United States, pancreatic cancer is not inherently a common malignant disease. Yet, it continuously is shown to be one of the most lethal and common causes of cancer ... -
The Potential Inhibitory Effect of Dihomo-Gamma-Linolenic Acid on Colon Cancer Cell Growth via Free Radical Metabolites in Cyclooxygenase-Catalyzed Peroxidation
(North Dakota State University, 2012)Cyclooxygenase (COX) can metabolize dihomo-γ-linolenic acid (DGLA) and arachidonic acid (AA) through free radical-mediated lipid peroxidation to form the anti-carcinogenic 1-series of prostaglandins and pro-carcinogenic ... -
Rage (Receptor for Advanced Glycation End Products) in Melanoma Progression
(North Dakota State University, 2014)The Receptor for Advanced Glycation End Products (RAGE) and its ligands are expressed in multiple cancer types and are implicated in cancer progression. Our lab has previously reported higher transcript levels of RAGE and ... -
Regulation of Vascular Tone in Cerebral and Coronary Arteries by Apelin/APJ Receptor Mechanisms
(North Dakota State University, 2018)The peptide, apelin, is expressed in fat cells, endothelial cells, and CNS neurons. Increasing evidence (e.g. inotropic and vasomotor effects) supports a role for apelin in the regulation of the cardiovascular system. This ... -
Role of Large Conductance, Calcium-Activated Potassium Channels (BKCa) in Vasorelaxation of Nitrate Tolerant Mesenteric Arteries
(North Dakota State University, 2016)Video summarizing Ph.D. dissertation for a non-specialist audience. -
The Role of the Gut Microbiota in Sustained Weight Loss Following Roux-en-Y Gastric Bypass Surgery
(North Dakota State University, 2018)Roux-en-Y Gastric Bypass (RYGB) surgery is one of the most effective approaches for the treatment of severe obesity. Despite substantial weight loss following RYGB, a considerable proportion of patients experience weight ... -
Smart, Biocompatible Polymersomes for Targeted Delivery of Therapeutic Agents to Cancerous Tumors
(North Dakota State University, 2017)Chemotherapeutics are the major treatment options for cancer. Although we cannot underestimate the importance of the chemotherapeutic drugs, their systemic toxicity is an important limiting factor for their use. Therefore, ... -
Synthesis and Evaluation of Cationic Nanomicelles for In Vitro and In Vivo Gene Delivery
(North Dakota State University, 2013)The goal of proposed study was to contribute towards the development of a nano size, high efficiency and low toxicity non-viral polymeric vector for gene delivery in vitro and in vivo. A series of fatty acid grafted ... -
Targeted Stimuli-Responsive Carriers for Efficient Delivery of Chemotherapeutic Drugs
(North Dakota State University, 2017)Chemotherapeutic agents for treating various cancers show considerable side effects and toxicity. Often cancer relapses after initial response to the chemotherapy. Tumor cells are heterogeneous and have the progenitor stem ... -
Targeted Three-Way-Junction RNA Nanoparticle Reprogrammed Cyclooxygenase-2 Catalyzed Dihomo-ϒ-Linolenic Acid Peroxidation Pattern in Lung Cancer
(North Dakota State University, 2021)As the second most common cancer and the first leading cause of cancer deaths, lung cancer attracts much research attention. Since cyclooxygenase-2 (COX-2) is overexpressing in nearly 80% of lung cancer patients, COX-2 ... -
Understanding the Role of Rage in Cell Adhesion
(North Dakota State University, 2022)The Receptor for Advanced Glycation Endproducts (RAGE) is a mammalian specific cell surface receptor. RAGE consists of three extracellular domains (V, C1, and C2), a transmembrane domain, and an intracellular cytoplasmic ... -
Understanding the Role of Receptor for Advanced Glycation Endproducts (RAGE) in Pancreatic Cancer and Melanoma
(North Dakota State University, 2021)In this project we study the role of RAGE in the melanoma and pancreatic cancer progression. Based on published studies, we hypothesized that RAGE localization in melanoma varies with different cellular architectures. To ... -
Understanding the Role of the Receptor for Advanced Glycation End-Products (Rage) in Pancreatic Cancer
(North Dakota State University, 2019)Expression of the Receptor for Advanced Glycation End Products (RAGE) and is upregulated in a several cancers. Based on published studies, we hypothesized that RAGE, when overexpressed in pancreatic cancer cells, will ...