Browsing Pharmacy Doctoral Work by Issue Date
Now showing items 41-51 of 51
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Understanding the Role of Receptor for Advanced Glycation Endproducts (RAGE) in Pancreatic Cancer and Melanoma
(North Dakota State University, 2021)In this project we study the role of RAGE in the melanoma and pancreatic cancer progression. Based on published studies, we hypothesized that RAGE localization in melanoma varies with different cellular architectures. To ... -
Determination of Growth Inhibitory Effect of Iminodibenzyl Against Breast Cancer
(North Dakota State University, 2021)Breast cancer arises from the culmination of complex process enclosing multiple gene modifications such as cyclooxygenase-2 (COX-2). It catalyzes arachidonic acid (AA, downstream ω-6 polyunsaturated fatty acid (ω-6 PUFA)) ... -
Chemical Modification of Bovine Milk Exosomes, the Biological Nanoparticles of the Future, as a Contrast Agent and Drug Delivery Vehicle
(North Dakota State University, 2021)Chemically derived nanoparticles are widely used across many applications. While they showed great promise when first discovered, the main hurdles, such as clearance and targeting, have yet to be overcome. A recently ... -
Targeted Three-Way-Junction RNA Nanoparticle Reprogrammed Cyclooxygenase-2 Catalyzed Dihomo-ϒ-Linolenic Acid Peroxidation Pattern in Lung Cancer
(North Dakota State University, 2021)As the second most common cancer and the first leading cause of cancer deaths, lung cancer attracts much research attention. Since cyclooxygenase-2 (COX-2) is overexpressing in nearly 80% of lung cancer patients, COX-2 ... -
GLUT-1 Targeted Gene Delivery to Brain for the Treatment of Alzheimer's Disease
(North Dakota State University, 2021)Alzheimer’s disease (AD) is a neurodegenerative disorder resulting in debilitating dementia with progressive loss of motor functions. Genetic modulation of neurotrophic factors and apolipoprotein E (ApoE) have emerged as ... -
Development of Nano-Architecture Systems for High-Efficiency Tumor-Targeted Drug Delivery
(North Dakota State University, 2021)Breast cancer is the most common malignancy and the second leading cause of death among women in the United States. The commonly used breast cancer treatment strategies include surgery, chemotherapy, radiation, and hormonal ... -
Estrogen Receptors Signaling in Airway Smooth Muscles: Role in Intracellular Calcium Regulation and Contractility
(North Dakota State University, 2021)Epidemiological evidence suggests higher incidence and severity of asthma in pre-menopausal women and aging men, suggesting a role of sex steroids, especially estrogen. In this regard, it is not clear whether specific ... -
Apelin-APJ Signaling in Hypertensive Coronary Arteries
(North Dakota State University, 2022)Apelin is an endogenous ligand for APJ receptors, which are highly expressed throughout the cardiovascular system, including coronary arteries. Apelin causes endothelium‐derived nitric oxide (NO) –dependent relaxation ... -
Kisspeptins: Airway Remodeling in Asthma
(North Dakota State University, 2022)Asthma is a chronic respiratory disorder that affects people of all ages. Sex and gender disparity in asthma is recognized and suggests a modulatory role for sex steroids, particularly estrogen. However, there is a dichotomous ... -
Understanding the Role of Rage in Cell Adhesion
(North Dakota State University, 2022)The Receptor for Advanced Glycation Endproducts (RAGE) is a mammalian specific cell surface receptor. RAGE consists of three extracellular domains (V, C1, and C2), a transmembrane domain, and an intracellular cytoplasmic ... -
BKCa-IP3R Decoupling in Hypertension
(North Dakota State University, 2022)Hypertension is a significant risk factor for cardiovascular diseases and a leading cause of worldwide morbidity and mortality. Dysregulation of intracellular Ca2+ in vascular smooth muscle (VSM) cells is one major contributor ...