Chemistry & Biochemistry: Recent submissions
Now showing items 41-60 of 87
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Understanding Binding-Induced Disorder-to-Order And Conformational Transitions in Proteins that Regulate Autophagy
(North Dakota State University, 2018)Autophagy, a cellular homeostasis process that degrades and recycles cytosolic contents, is regulated at various stages by protein interactions. BECN1 regulates autophagy through interactions with diverse proteins via ... -
Identification of Aptamer Specific for Carcinoembryonic Antigen and its Analytical Applications
(North Dakota State University, 2017)Carcinoembryonic Antigen (CEA) is an approved cancer biomarker by the Food and Drug Administration (FDA) for the early detection, diagnosis, and for the use in the regular screening of patients at high risk for the development ... -
Micro-/Nano- Materials Based Ultrasensitive Lateral Flow Nucleic Acid Biosensors
(North Dakota State University, 2017)Ultrasensitive detection of nucleic acids plays a very important role in the field of molecular diagnosis for the detection of various diseases. Lateral flow biosensors (LFB) are convenient, easy-to-use, patient friendly ... -
Carbon Nanotubes-Based Lateral Flow Biosensor for Sensitive and Rapid Detection of DNA Sequence
(North Dakota State University, 2017)Sensitive detection for DNA has drawn great attention in plenty of different areas such as genetics therapy and basic discovery research. Recently, nucleic acid lateral flow biosensor (NALFB) has gained considerable attention ... -
Adsorption Kinetics and Dynamics of Small Molecules on Graphene and Graphene oxide
(North Dakota State University, 2018)Graphene is an allotrope of carbon composed of sp2 hybridized carbon and arranged into a honeycomb lattice. Graphene is a mechanically strong material (200 times stronger than steel) and has high carrier mobility, high ... -
Novel Synthetic Routes to Complex Amines: the Catalytic Hydroamination of Alkynes and Hydroimination of Allenes
(North Dakota State University, 2016)Amines are valuable targets for synthesis in contexts of both research and industrial applications. This work proposes two atom-economical methods—hydroamination (HAM) and hydroimination (HIM)—as C-N bond formation strategies. ... -
Late Transition Metal-Catalyst Development for Alkyne Coupling Reactions
(North Dakota State University, 2016)Alkynes are versatile and valuable synthetic precursors in a variety of organic transformations and have found tremendous applications in materials science and pharmaceutical chemistry. In recent years, there has been a ... -
Photons in Action: Asymmetric Synthesis and Polymer Degradation
(North Dakota State University, 2016)Light is an environmentally benign and renewable source of energy that finds wide application in the field of science. This dissertation explores two areas of chemistry that utilizes light extensively viz., asymmetric ... -
Structural Studies of the Mechanism by Which BCL-2 and Beclin Proteins Regulate Autophagy and Apoptosis
(North Dakota State University, 2016)Autophagy and apoptosis are catabolic pathways essential for homeostasis in all eukaryotes. While autophagy usually promotes cell-survival by enabling degradation and recycling of damaged macromolecules, apoptosis is the ... -
Infrared Diode Laser Spectroscopic Study of Combustion Related Kinetics
(North Dakota State University, 2016)In the introduction section background into the subject of combustion chemistry is presented. The topics included are combustion mechanisms, combustion pollutants, and infrared absorption spectroscopy. Chapter two describes ... -
Visual Detection of Cancer Biomarkers with Aptamer-Functionalized Gold Nanoparticles
(North Dakota State University, 2015)Cancer biomarkers may hold the key for the early detection of cancer, distinguishing between benign and malignant cells, and differentiating tumor types. The detection of cancer biomarkers can be used for cancer diagnosis, ... -
Lateral Flow Nucleic Acid Biosensor for the Detection of Sexually Transmitted Diseases
(North Dakota State University, 2015)Nucleic acid detection is of central importance for the diagnosis and treatment of genetic diseases, infectious agents, bio-warfare agents, and drug discovery. Nucleic acid testing for diseases is exclusively performed in ... -
Stereospecific Phototransformations of Atropisomeric Chromophores
(North Dakota State University, 2014)Photochemical transformations are unique strategy in synthesis that enables us to access complex and structurally diverse organic scaffolds. However, the challenges in controlling the excited-state to perform stereoselective ... -
Characterizing the Roles of Exit Tunnel Residues in Ligand Binding and Catalysis of Histone Deacetylase-8
(North Dakota State University, 2014)Histone deacetylases are an important class of enzymes that catalyze the hydrolysis of acetyl-L-lysine side chains in histone and non-histone proteins to yield L-lysine and acetate, effecting the epigenetic regulation of ... -
Biochemical and Functional Characterization of Rpa2 N-Terminal Phosphorylation during DNA Repair and Checkpoint Adaptation in Saccharomyces Cerevisiae
(North Dakota State University, 2018)In response to DNA damage, a signaling cascade is activated within cells that promotes cell cycle arrest in order to provide adequate time for DNA repair to occur. Replication Factor A (RFA) is an essential, heterotrimeric ... -
Strategic Functionalization of Single Walled Carbon Nanotubes to Manipulate their Electronic and Optical Properties
(North Dakota State University, 2017)Single-walled carbon nanotubes (SWCNTs) are unique materials that exhibit chirality-specific properties due to their one-dimensional confinement. As a result, they are explored for a wide range of applications including ... -
Interactions of Light with Organic Chromophores: A Photochemical and Photophysical Investigation
(North Dakota State University, 2018)Over the past century, light has emerged as a useful tool finding utility in various fields such as device fabrication, the medical field, as well as utility as an energy source. Chemist have adopted this abundant energy ... -
Applications of Dithieno [3,2-B2',3'-D] Pyrroles and its Analogues to Conjugated Materials
(North Dakota State University, 2014)The promise of semiconducting materials with tunable electronic and optical properties that share the same mechanical flexibility, low production costs and ease of processing displayed by traditional polymers fuels the ... -
Identification of Active Sites in Heterogeneous Catalysis and Surface Chemistry Study of Alkanes Adsorption
(North Dakota State University, 2014)Heterogeneous catalysis is considered the basis of the chemical industry. Surface science investigations on model catalysts have made significant contributions in gaining molecular level understanding of heterogeneously ... -
Synthesis and Characterization of 2,3-Difunctionalized Thieno[3,4-b]Pyrazine-Based Terthienyls Structure-Function Relationships and Side Chain Tunability
(North Dakota State University, 2014)The ability to tune the physical, electronic, and optical properties of polymer precursors has garnered a great deal of interest in the conjugated organic materials field. The Rasmussen group has previously demonstrated ...